Search results for "Transplantation Antigens"

Identification of Point Mutations in Genes Coding for tum-Antigens. A Step Towards the Understanding of Mouse and Human Tumor-Specific Transplantatio…

1989

Most experimental tumors induced with chemical carcinogens or UV radiation express individually specific transplantation antigens that elicit a T cell-mediated immune rejection in the syngeneic animals (Prehn and Main 1957; Klein et al. 1960; Kripke 1981; Uyttenhove et al. 1983). The characterization of these transplantation antigens has proved very difficult and several different approaches have been followed. One involves the search for specific antibodies to isolate the antigen by immunoprecipitation. Unfortunately, tumors seldom elicit antibodies directed against their specific transplantation antigens. One notable exception is UV-induced tumor 1591, and the molecules that were isolated…